![]() ![]() Maixner W, Gracely RH, Zuniga JR, Humphrey CB, Bloodworth GR (1990) Cardiovascular and sensory responses to forearm ischemia and dynamic hand exercise. Kilchukov M, Kiselev R, Gorbatykh A, Klinkova A, Murtazin V, Kamenskaya O, Orlov K (2023) High-frequency versus low-frequency spinal cord stimulation in treatment of chronic limb-threatening ischemia: short-term results of a randomized trial. Kapural L, Yu C, Doust MW, Gliner BE, Vallejo R, Sitzman BT, Amirdelfan K, Morgan DM, Yearwood TL, Bundschu R, Yang T, Benyamin R, Burgher AH (2016) Comparison of 10-kHz high-frequency and traditional low-frequency spinal cord stimulation for the treatment of chronic back and leg pain: 24-month results from a multicenter, randomized, controlled pivotal trial. Kapural L, Yu C, Doust MW, Gliner BE, Vallejo R, Sitzman BT, Amirdelfan K, Morgan DM, Brown LL, Yearwood TL, Bundschu R, Burton AW, Yang T, Benyamin R, Burgher AH (2015) Novel 10-kHz high-frequency therapy (HF10 therapy) is superior to traditional low-frequency spinal cord stimulation for the treatment of chronic back and leg pain: the SENZA-RCT randomized controlled trial. Holwerda SW, Holland MT, Green AL, Pearson ACS, Pierce GL (2021) Dissociation between reduced pain and arterial blood pressure following epidural spinal cord stimulation in patients with chronic pain: a retrospective study. ![]() Holwerda SW, Holland MT, Reddy CG, Pierce GL (2018) Femoral vascular conductance and peroneal muscle sympathetic nerve activity responses to acute epidural spinal cord stimulation in humans. Holland MT, Rettenmaier LA, Flouty OE, Thomsen TR, Jerath NU, Reddy CG (2016) Epidural spinal cord stimulation: a novel therapy in the treatment of restless legs syndrome. Guasti L, Zanotta D, Diolisi A, Garganico D, Simoni C, Gaudio G, Grandi AM, Venco A (2002) Changes in pain perception during treatment with angiotensin converting enzyme-inhibitors and angiotensin II type 1 receptor blockade. Guasti L, Grimoldi P, Diolisi A, Petrozzino MR, Gaudio G, Grandi AM, Rossi MG, Venco A (1998) Treatment with enalapril modifies the pain perception pattern in hypertensive patients. Goudman L, Brouns R, Linderoth B, Moens M (2019) Effects of spinal cord stimulation on heart rate variability in patients with failed back surgery syndrome. Įpstein LJ, Palmieri M (2012) Managing chronic pain with spinal cord stimulation. Clin J Pain 21:147–153Įckermann JM, Pilitsis JG, Vannaboutathong C, Wagner BJ, Province-Azalde R, Bendel MA (2021) Systematic literature review of spinal cord stimulation in patients with chronic back pain without prior spine surgery. Hypertension 14:177–183īruehl S, Chung OY, Jirjis JN, Biridepalli S (2005) Prevalence of clinical hypertension in patients with chronic pain compared to nonpain general medical patients. Evidence from direct intraneural recordings. These findings confirm previous studies showing reduced BP following implantation of LF-SCS in patients with chronic pain and hypertension and provide novel data regarding reduced BP following implantation of newer generation HF-SCS devices.Īnderson EA, Sinkey CA, Lawton WJ, Mark AL (1989) Elevated sympathetic nerve activity in borderline hypertensive humans. Higher pain scores before implantation were not associated with reduction in systolic BP ( R = 0.10, P = 0.43) or diastolic BP ( R = −0.08, P = 0.53) ( n = 69) after implantation. Importantly, the change in BP was inversely related to baseline BP independent of age and sex following implantation of HF-SCS ( n = 70, R = −0.50, P < 0.001) or LF-SCS ( n = 62, R = −0.42, P = 0.001). Patients with hypertension ( n = 32) demonstrated a significantly greater reduction in systolic BP (−8 ± 12 versus 2 ± 9 mmHg, P < 0.001) following implantation compared with normotensive patients ( n = 100). ResultsĪ total of 132 patients had available records of clinic BP (64 ± 13 years of age). MethodsĬlinic BP within 3 months before and after surgical implantation of either a LF-SCS or HF-SCS device between 20 were collected from electronic medical records at The University of Kansas Health System (TUKHS). Therefore, in a retrospective study design, we tested the hypothesis that clinic BP would be significantly reduced following implantation of HF-SCS in patients with chronic pain and hypertension. However, it remains unclear whether high-frequency spinal cord stimulation (HF-SCS) also lowers BP in chronic pain patients with hypertension. Evidence suggests that traditional low-frequency spinal cord stimulation (LF-SCS) reduces arterial blood pressure (BP) in patients with chronic pain and hypertension independent of improved pain symptoms.
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